Physiological roles of MKK4 and MKK7: insights from animal models.

  title={Physiological roles of MKK4 and MKK7: insights from animal models.},
  author={Xin Wang and Auriane P M Destrument and Cathy Tournier},
  journal={Biochimica et biophysica acta},
  volume={1773 8},
c-Jun NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase (MAPK) involved in the regulation of numerous physiological processes during development and in response to stress. Its activity is increased upon phosphorylation by the MAPK kinases, MKK4 and MKK7. Similar to the early embryonic death of mice caused by the targeted deletion of the jnk genes, mice lacking mkk4 or mkk7 die before birth. The inability of MKK4 and MKK7 to compensate for each other's functions in vivo is… CONTINUE READING
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