Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.

@article{Yang2009PhysiologicalRO,
  title={Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.},
  author={Jiang-Ning Yang and Jiang-fan Chen and Bertil B. Fredholm},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 4},
  pages={H1141-9}
}
Heart rate (HR), body temperature (Temp), locomotor activity (LA), and oxygen consumption (O(2)C) were studied in awake mice lacking one or both of the adenosine A(1) or A(2A) receptors (A(1)R or A(2A)R, respectively) using telemetry and respirometry, before and after caffeine administration. All parameters were lower during day than night and higher in females than males. When compared with wild-type (WT) littermates, HR was higher in male A(1)R knockout (A(1)RKO) mice but lower in A(2A)RKO… CONTINUE READING

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