Physiological role of tumor necrosis factor alpha in traumatic muscle injury.

  title={Physiological role of tumor necrosis factor alpha in traumatic muscle injury.},
  author={Gordon L Warren and Tracy Hulderman and Nancy J Jensen and Michael McKinstry and Michael Mishra and Michael I. Luster and Petia Simeonova},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={16 12},
degenerative and regenerative roles of tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory cytokine with pleiotropic functions, were investigated by using TNF receptor 1 and 2 double knockout (TNFR-DKO) and TNF-alpha antibody neutralized mice following traumatic freeze injury to the tibialis anterior muscle. In wild-type control mice, TNF-alpha mRNA transcripts and protein increased following injury and gradually returned to control (uninjured) levels by 13 days. A reduction in MyoD… CONTINUE READING
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