Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction

@inproceedings{Dufresne2016PhysiologicalRO,
  title={Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction},
  author={S{\'e}bastien S. Dufresne and Antoine Boulanger-Piette and Sabrina Boss{\'e} and Jĕr{\^o}me Frenette},
  booktitle={Receptors & clinical investigation},
  year={2016}
}
The bone remodeling and homeostasis are mainly controlled by the receptor-activator of nuclear factor kB (RANK), its ligand RANKL, and the soluble decoy receptor osteoprotegerin (OPG) pathway. While there is a strong association between osteoporosis and skeletal muscle dysfunction, the functional relevance of a particular biological pathway that synchronously regulates bone and skeletal muscle physiopathology remains elusive. Our recent article published in the American Journal of Physiology… CONTINUE READING