Physiological role of carnosine in contracting muscle.

  title={Physiological role of carnosine in contracting muscle.},
  author={Gulshanara Begum and Adam Cunliffe and Michael D Leveritt},
  journal={International journal of sport nutrition and exercise metabolism},
  volume={15 5},
High-intensity exercise leads to reductions in muscle substrates (ATP, PCr6, and glycogen) and a subsequent accumulation of metabolites (ADP, P, H(+), and Mg(+)) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H… 

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The results indicated that the carnosine concentration could be an important factor in determining the high-intensity exercise performance.

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Findings demonstrate that, in the diaphragm as well as in the locomotor muscles, the attenuations of the SR function is brought about by acute high-intensity exercise, which may contribute, at least in part, to deteriorations in exercise tolerance and work productivity resulting from repetitive physical activities.

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Mechanisms of muscle fatigue in intense exercise.

  • H. Green
  • Biology
    Journal of sports sciences
  • 1997
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