Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.

@article{Malmsten1975PhysiologicalRO,
  title={Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.},
  author={Curt Malmsten and Mats H{\'a}mberg and Jan E Svensson and Bengt Samuelsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1975},
  volume={72 4},
  pages={1446-50}
}
The endoperoxide prostaglandin G2 (PGG2) induced platelet aggregation as well as the platelet release reaction (release of ADP and serotonin) when added to human platelet-rich plasma. Formation of a metabolite of PGG2 [8-(l-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid] and a lipoxygenase product [12L-hydroxy-5,8,10,14-eicosatetraenoic acid] accompanied the release reaction caused by aggregating agents such as collagen, ADP, epinephrine, and thrombin. Indomethacin inhibited… CONTINUE READING