Physiological role of alpha 2-adrenoceptors in the regulation of vigilance and pain: effect of medetomidine.

  • Dag Stenberg
  • Published 1989 in Acta veterinaria Scandinavica. Supplementum


The sedative action of alpha 2-adrenergic agonists is generally ascribed to inhibition of the locus coeruleus (LC) and its ascending activating projection to the forebrain, although postsynaptic effects in the neocortex may also play a part. The sedative effect of the drugs varies considerably between different species. Systemic application of alpha 2… (More)


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