Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

@article{Reaux2001PhysiologicalRO,
  title={Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.},
  author={Annabelle Reaux and Nadia de Mota and I Skult{\'e}tyov{\'a} and Zsolt Lenkei and Said El Messari and Katalin Gallatz and Pierre Corvol and Mikl{\'o}s Palkovits and C Llorens-cortes},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 4},
  pages={1085-96}
}
Apelin, a peptide recently isolated from bovine stomach tissue extracts, has been identified as the endogenous ligand of the human orphan APJ receptor. We established a stable Chinese hamster ovary (CHO) cell line expressing a gene encoding the rat apelin receptor fused to the enhanced green fluorescent protein, to investigate internalization and the pharmacological profile of the apelin receptor. Stimulation of this receptor by the apelin fragments K17F (Lys1-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS