Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta.

@article{Komuro1997PhysiologicalRO,
  title={Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta.},
  author={Toshinobu Komuro and Soichi Miwa and Xin Zhang and Takasi Minowa and Takashi Konan-ku Enoki and Shigeaki Kobayashi and Yasuo Okamoto and Hiromichi Ninomiya and Tatsuya Sawamura and Kō-ichi Kikuta and Yasushi Iwamuro and Hidekatsu Furutani and Hiroshi Hasegawa and Yasuo Uemura and Hideyuki Kikuchi and Tomoh Masaki},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={30 4},
  pages={
          504-9
        }
}
We previously showed a role for a nonselective cation channel (NSCC) in the ETA-dependent action of endothelin-1 in mouse fibroblast and rabbit aortic smooth-muscle cell. To clarify the physiological significance of NSCCs in endothelin-1 (ET-1)-induced vasocontraction, we examined the effects of NSCC blockers such as mefenamic acid and SK&F 96365 on the contractions of deendothelialized rabbit aortic rings induced by a low (10[-10] M) or high (10[-8] M) concentration of ET-1. Mefenamic acid… CONTINUE READING
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