Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons.

@article{Farah2008PhysiologicalRF,
  title={Physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl II in Aplysia neurons.},
  author={Carole A. Farah and Ikue Nagakura and Daniel B. Weatherill and Xiaotang Fan and Wayne S. Sossin},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 15},
  pages={4719-33}
}
In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. The orthologue of PKC Apl II, PKCepsilon, has been reported to require phosphatidic acid (PA) in conjunction with diacylglycerol (DAG) for translocation. We find that PKC Apl II can be synergistically translocated to membranes by the combination of DAG and PA. We identify a mutation in the C1b domain (arginine 273 to histidine; PKC Apl II… CONTINUE READING

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