Physiological responses to emotional excitement in healthy subjects and patients with coronary artery disease

  title={Physiological responses to emotional excitement in healthy subjects and patients with coronary artery disease},
  author={Olli-Pekka Piira and Johanna A. Miettinen and Arto J. Hautala and Heikki Veli Huikuri and Mikko Paavo Tulppo},
  journal={Autonomic Neuroscience},

Effects of emotional excitement on cardiovascular regulation

The incidence of adverse cardiovascular events is higher among spectators of exciting sports events, particularly in patients with coronary artery disease (CAD), but the mechanistic link between the

Exercise capacity is associated with endothelin-1 release during emotional excitement in coronary artery disease patients.

Exercise capacity may protect against further cardiovascular events in CAD patients, because it is associated with reduced ET-1 release during emotional excitement, as well as body mass index and left ventricular ejection fraction.

Computational Psychometrics Using Psychophysiological Measures for the Assessment of Acute Mental Stress

Computational psychometrics analyses proved to be an effective tool for studying such complex variables and could represent the first step in developing complex platforms for the automatic detection of mental stress, which could improve the treatment.

Emotion, Social Relationships, and Physical Health: Concepts, Methods, and Evidence for An Integrative Perspective.

The present review builds on prior calls for integration, related theory, and current research to outline what is known about the interconnection of these domains as it specifically relates to their overlapping influences on health.

Hockey Games and the Incidence of ST-Elevation Myocardial Infarction.

Perspective of Inflammation and Inflammation Markers

C-reactive protein, adiponectin, CD40 ligand, and lipoprotein-associated phospholipase A were the focus of this review, which also looked at statins' effect on these biomarkers and their potential link to cardiovascular events.

The extended autonomic system, dyshomeostasis, and COVID-19

  • D. Goldstein
  • Medicine, Biology
    Clinical Autonomic Research
  • 2020
Testable hypotheses derived from these concepts are that biomarkers of EAS activation correlate with clinical and pathophysiologic data and predict outcome in COVID-19 and that treatments targeting specific abnormalities identified in individual patients may be beneficial.

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

The pooled ORs demonstrated no association of −174G/C polymorphism and CAD, and the growing evidences suggest that polymorphisms in the IL-6 promoter region influence the progression of CAD.

Using infrared thermography to assess emotional responses to infants

Adult–infant interactions operate simultaneously across multiple domains and at multiple levels – from physiology to behaviour. Unpackaging and understanding them, therefore, involve analysis of

Systematic review and meta-analysis of association of polymorphisms in inflammatory cytokine genes with coronary artery disease

The meta-analysis revealed the positive association of IL6 gene rs1800795 polymorphism in susceptibility to CAD and the recessive model (CC vs. CG + GG) in IL6Gene rs1800796 polymorphism had marginally significant association with decreased risk of CAD.



Leisure time emotional excitement increases endothelin-1 and interleukin-6 in cardiac patients

The responses of surrogate markers of acute CV events to emotional excitement and physical exercise are partly different, with emotional excitement causes concomitant increases in markers reflecting vulnerability to atherosclerotic plaque complications while physical exercise causes more prominent changes in markers of coagulation.

Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease.

Sympathovagal interaction during mental stress. A study using spectral analysis of heart rate variability in healthy control subjects and patients with a prior myocardial infarction.

The findings indicate that psychological stress induced marked changes in the sympathovagal balance, which moved toward sympathetic predominance.

Exaggerated Endothelin Release in Response to Acute Mental Stress in Patients with Intermittent Claudication

It is shown that acute mental stress causes an exaggerated release of ET-1 in patients with intermittent claudicant outpatients and suggested that this could be a potential pathophysiological mechanism through which mental stress may trigger adverse acute cardiac events and accelerate progression of atherosclerosis in these patients.

Mental Stress-Induced Platelet Activation Among Patients With Coronary Artery Disease

Study of patients with coronary artery disease scheduled for coronary angioplasty and platelet activation in response to mental stress found this mechanism may partially explain the link between psychosocial variables and the development of adverse cardiac outcomes in patients with CAD.

Assessment of the neural control of the circulation during psychological stress.

Heart rate dynamics during accentuated sympathovagal interaction.

The data show that HR behavior becomes remarkably unstable during accentuated sympathovagal interaction, resembling stochastic dynamics or deterministic chaotic behavior, which can be better identified by dynamic analysis of beat-to-beat behavior of R-R intervals than by traditional analysis techniques of HR variability.

Mental stress and physical exercise increase platelet-dependent thrombin generation

The increase in thrombin generation with exercise and mental stress was unaffected by treatment with 81 mg/day of aspirin of 7 days, however, it was inhibited by a single oral 40-mg dose of metoprolol.