Physiological responses of the hyperthermophilic archaeon "Pyrococcus abyssi" to DNA damage caused by ionizing radiation.

@article{Jolivet2003PhysiologicalRO,
  title={Physiological responses of the hyperthermophilic archaeon "Pyrococcus abyssi" to DNA damage caused by ionizing radiation.},
  author={Edmond Jolivet and Fujihiko Matsunaga and Yoshizumi Ishino and Patrick Forterre and Daniel Prieur and Hannu Myllykallio},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 13},
  pages={3958-61}
}
The mechanisms by which hyperthermophilic Archaea, such as "Pyrococcus abyssi" and Pyrococcus furiosus, survive high doses of ionizing gamma irradiation are not thoroughly elucidated. Following gamma-ray irradiation at 2,500 Gy, the restoration of "P. abyssi" chromosomes took place within chromosome fragmentation. DNA synthesis in irradiated "P. abyssi" cells during the DNA repair phase was inhibited in comparison to nonirradiated control cultures, suggesting that DNA damage causes a… CONTINUE READING