Physiological responses during hypoglycaemia induced by regular human insulin or a novel human analogue, insulin glargine.

@article{DagogoJack2000PhysiologicalRD,
  title={Physiological responses during hypoglycaemia induced by regular human insulin or a novel human analogue, insulin glargine.},
  author={Samuel Dagogo-Jack and Hasan Askari and Betsy Morrill and Laura Lehner and Bo Yi Kim and Xue Sha},
  journal={Diabetes, obesity & metabolism},
  year={2000},
  volume={2 6},
  pages={373-83}
}
AIM Glargine, a product of recombinant technology, has different structural and physicochemical properties compared with native human insulin. We determined whether such differences are associated with alterations in the responses to hypoglycaemia induced by glargine. METHODS Nineteen adults (six healthy and 13 with type 1 diabetes) underwent a 5-h hyperinsulinaemic (2 mU/kg/min(-1)) stepped hypoglycaemic clamps (hourly targets of 4.7, 4.2, 3.6, 3.1 and 2.5 mmol/l, respectively) on two… CONTINUE READING

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