• Corpus ID: 28506029

Physiological response of man to ammonia in low concentrations.

@article{Silverman1949PhysiologicalRO,
  title={Physiological response of man to ammonia in low concentrations.},
  author={Leslie. Silverman and James L. Whittenberger and J. Muller},
  journal={The Journal of industrial hygiene and toxicology},
  year={1949},
  volume={31 2},
  pages={
          74-8
        }
}

Toxicological profile for ammonia

The importance of taking an exposure history and how to conduct one are described, and an example of a thorough exposure history is provided, and the following information helpful for fast answers to often-asked questions are provided.

Ammonia exposure by intratracheal instillation causes severe and deteriorating lung injury and vascular effects in mice

NH3 induces severe acute lung injuries that deteriorate over time and biomarkers in lungs and blood that are similar to those found in humans that have potential use for developing diagnostic tools for NH3-induced ALI and for finding new therapeutic treatments, since no specific antidote has been identified yet.

Ammonia exposure and hazard assessment for selected household cleaning product uses

Routine household uses of ammonia are unlikely to produce significant exposures when using standard cleaning solutions, but spillage or use of concentrated ammonia solutions in poorly ventilated areas can lead to potentially hazardous airborne ammonia exposures.

A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change

Examining longitudinally in-cage activity, animal health and the build-up of ammonia across the cage floor with female and male C57BL/6 mice housed four per IVC changed every other week concludes that housing of four C57bl/6J mice for 10 weeks under the described conditions does not cause any overt discomfort to the animals.

Safety Aspects

Comparisons of acute inflammatory responses of nose-only inhalation and intratracheal instillation of ammonia in rats

These findings support that the intratracheal instillation exposure regimen can be used for new medical countermeasure strategies for NH3-induced acute lung injury (ALI).

TEARHS-Modelling toxic impacts on the airway system from exposure to fluctuating concentrations

This report describes Risøs contribution to the TEARHS project. The aim of the TEAHRS project is to develop and assess methodologies to determine the acute toxicity of inhalation of fluctuating