Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.

@article{Krmer2008PhysiologicalRO,
  title={Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.},
  author={Jens O. Kr{\"o}mer and Christoph Bolten and Elmar Heinzle and Hartwig Schr{\"o}der and Christoph Wittmann},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 12},
  pages={3917-30}
}
In the present work the metabolic response of Corynebacterium glutamicum to deletion of the global transcriptional regulator McbR, which controls, e.g. the expression of enzymes of L-methionine and L-cysteine biosynthesis and sulfur assimilation, was studied. Several oxidative stress proteins were significantly upregulated among about 40 proteins in response to deletion of McbR. Linked to this oxidative stress, the mutant exhibited a 50 % reduced growth rate, a 30 % reduced glucose uptake rate… CONTINUE READING

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