Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter

@article{Brendel2012PhysiologicalRO,
  title={Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter},
  author={Cornelia M Brendel and Uta Mueller-Kuller and Stephan Schultze-Strasser and Susanne Stein and Linping Chen-Wichmann and Anja Krattenmacher and Hana Kunkel and Adelina Dillmann and Michael N Antoniou and Manuel Grez},
  journal={Gene Therapy},
  year={2012},
  volume={19},
  pages={1018-1029}
}
Protection against epigenetic silencing is a desirable feature of future gene therapy vectors, in particular for those applications in which transgene expression will not confer growth advantage to gene-transduced cells. The ubiquitous chromatin opening element (UCOE) consisting of the methylation-free CpG island encompassing the dual divergently transcribed promoters of the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) has been shown to shield constitutive active heterologous promoters from… CONTINUE READING