Physiological regulation of the pancreatic β‐cell: functional insights for understanding and therapy of diabetes

@article{Mcclenaghan2007PhysiologicalRO,
  title={Physiological regulation of the pancreatic $\beta$‐cell: functional insights for understanding and therapy of diabetes},
  author={Neville H Mcclenaghan},
  journal={Experimental Physiology},
  year={2007},
  volume={92}
}
  • N. Mcclenaghan
  • Published 1 May 2007
  • Biology, Medicine
  • Experimental Physiology
Knowledge about the sites and actions of the numerous physiological and pharmacological factors affecting insulin secretion and pancreatic β‐cell function has been derived from the use of bioengineered insulin‐producing cell lines. Application of an innovative electrofusion approach has generated novel glucose‐responsive insulin‐secreting cells for pharmaceutical and experimental research, including popular BRIN‐BD11 β‐cells. This review gives an overview of the establishment and core… Expand
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