Physiological regulation of cyclooxygenase-2 in the kidney.

  title={Physiological regulation of cyclooxygenase-2 in the kidney.},
  author={Raymond C Harris and Matthew D. Breyer},
  journal={American journal of physiology. Renal physiology},
  volume={281 1},
In adult mammalian kidney, cyclooxygenase-2 (COX-2) expression is found in a restricted subpopulation of cells. The two sites of renal COX-2 localization detected in all species to date are the macula densa (MD) and associated cortical thick ascending limb (cTALH) and medullary interstitial cells (MICs). Physiological regulation of COX-2 in these cellular compartments suggests functional roles for eicosanoid products of the enzyme. COX-2 expression increases in high-renin states (salt… CONTINUE READING