Physiological processes and dynamics in the disposition of small and large doses of biologically active and inactive 131-I-insulins in the rat.

@article{Izzo1967PhysiologicalPA,
  title={Physiological processes and dynamics in the disposition of small and large doses of biologically active and inactive 131-I-insulins in the rat.},
  author={Joseph L. Izzo and J W Bartlett and A M Roncone and Marcello Izzo and William F. Bale},
  journal={The Journal of biological chemistry},
  year={1967},
  volume={242 10},
  pages={2343-55}
}
The physiological disposition of single intravenous injections of biologically active 131-labeled insulin of high specific activity containing an average of 0.8 atom of total iodine per molecule of insulin (mol wt 6000) and of biologically inactive 1311-insulin containing an average of 6 atoms of iodine per molecule were cc.mpared in the rat over a 3-hour interval at two dose levels: tracer or physiological levels (50 to 100 microunits/lOO g of rat body weight), and large or pharmacological… CONTINUE READING