Physiological polyamines: simple primordial stress molecules

  title={Physiological polyamines: simple primordial stress molecules},
  author={Hae Jin Rhee and E K Kim and Jeong Kyu Lee},
  booktitle={Journal of cellular and molecular medicine},
Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression, cell proliferation and modulation of cell signalling. Reports that the polyamines with cytoprotective activities were induced by diverse stresses raised the hypothesis that physiological polyamines may play a role in inducing stress response. In a wide range of organisms, physiological polyamines were not only induced by diverse stresses, such as reactive oxygen… CONTINUE READING