Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtainedin vitro as well as on physiological data

@article{Lin1982PhysiologicalPO,
  title={Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtainedin vitro as well as on physiological data},
  author={Jiunn Huei Lin and Yuichi Sugiyama and Shoji Awazu and Manabu Hanano},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1982},
  volume={10},
  pages={649-661}
}
Ethoxybenzamide (EB) concentrations in plasma and various tissues were simulated using a physiological pharmacokinetic model. The biochemical parameters, such as plasma and tissue binding constants and Michaelis-Menten constants for EB deethylation, which were needed for these simulations, were, however, obtained from in vitro data. The simulations predicted well the observed data in plasma and various tissues of the rat. Furthermore, animal scale-up predicted reasonably well the concentrations… CONTINUE READING

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