Physiological pathways regulating the activity of magnocellular neurosecretory cells

@article{Leng1999PhysiologicalPR,
  title={Physiological pathways regulating the activity of magnocellular neurosecretory cells},
  author={Gareth Leng and Colin H. Brown and John A. Russell},
  journal={Progress in Neurobiology},
  year={1999},
  volume={57},
  pages={625-655}
}
Magnocellular oxytocin and vasopressin cells are among the most extensively studied neurons in the brain; their large size and high synthetic capacity, their discrete, homogeneous distribution and the anatomical separation of their terminals from their cell bodies, and the ability to determine their neuronal output readily by measurements of hormone concentration in the plasma, combine to make these systems amenable to a wide range of fundamental investigations. While vasopressin cells have… Expand
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References

SHOWING 1-10 OF 269 REFERENCES
Magnocellular neuroendocrine neurons: update on intrinsic properties, synaptic inputs and neurophamacology
TLDR
In the rat, medullary noradrenergic and forebrain GABAergic neurons, as well as neurons located in a circumventricular structure, the subfornical organ, appear to constitute major pathways conveying visceral, osmotic and cardiovascular information to MNCs. Expand
Calcium-channel subtypes in the somata and axon terminals of magnocellular neurosecretory cells
TLDR
Characterization of elicited Ca2+ currents in rat supraoptic nucleus cells has demonstrated that certain types are segregated in somata or axon terminals, and that current types defined pharmacologically can display different kinetic properties in the two loci. Expand
Involvement of the A1 cell group in baroreceptor inhibition of neurosecretory vasopressin cells
TLDR
The data suggest that the A1 cell group is not an essential component in pathways mediating baroreceptor inhibition of neurosecretory AVP cells, but may contribute to the sensitivity of AVP Cells to this input. Expand
Dendritic Release of Vasopressin and Oxytocin
  • Ludwig
  • Biology, Medicine
  • Journal of neuroendocrinology
  • 1998
TLDR
Spatial and temporal differences between peptide release within the nuclei and that from the distant axonal varicosities indicate that the release mechanisms are at least partially independent, supporting the hypothesis of locally regulated dendritic release of vasopressin and oxytocin. Expand
Activity of phasic neurosecretory cells during haemorrhage
TLDR
The results show the importance of pattern modulation in phasic neurones and suggest that the mechanism for vasopressin release differs from that described for oxytocin release during suckling. Expand
Mechanosensitive channels transduce osmosensitivity in supraoptic neurons
TLDR
It is reported that changes in cell volume accompany physiological variations in fluid osmolality and that these modulate the activity of mechanosensitive cation channels in a way that is consistent with the macroscopic regulation of membrane voltage and action potential discharge. Expand
Mechanisms of vasopressin secretion.
TLDR
The electrophysiological characteristics of vasopressin neurons, the characteristics of stimulus-secretion coupling in the neural lobe, and some of the major features of the neural regulation of this system which underlie physiological regulation of vasOPressin release by osmoregulatory stimuli are described. Expand
Paraventricular neurosecretory neurons: Synaptic inputs from the ventrolateral medulla in rats
TLDR
The result suggests that both vasopressin- and oxytocin-secreting neurons in the PVN receive mainly excitatory synaptic inputs from the ventrolateral medulla. Expand
Intercommunication in the rat supraoptic nucleus.
  • G. Leng, R. Dyball
  • Biology, Medicine
  • Quarterly journal of experimental physiology
  • 1983
TLDR
In contrast to earlier reports, recent electrophysiological and anatomical evidence suggests that strong coupling is not widespread within the nucleus, however, it remains possible that local release of a neuromodulator, perhaps vasopressin itself, may modify the phasic discharge patterns of the vasopressed cells. Expand
Membrane properties of rat magnocellular neuroendocrine cells in vivo
TLDR
Membrane properties of rat magnocellular neuroendocrine cells were examined during intracellular recordings in vivo and cells recorded in vivo were characterized by intense synaptic inhibition and a lower specific impedance than commonly observed from MNCs impaled in vitro. Expand
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3
4
5
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