Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge.

@article{Thomas2010PhysiologicalNO,
  title={Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge.},
  author={Paul G. Thomas and Scott Anthony Brown and Melissa Y. Morris and Wen Yue and Jenny M P So and Cory E Reynolds and Richard R. J. Webby and Peter C. Doherty},
  journal={Journal of immunology},
  year={2010},
  volume={184 4},
  pages={1721-7}
}
Naive and recall CD4(+) T cell responses were probed with recombinant influenza A viruses incorporating the OVA OT-II peptide. The extent of OT-II-specific CD4(+) T cell expansion was greater following primary exposure, with secondary challenge achieving no significant increase in numbers, despite higher precursor frequencies. Adoptive transfer experiments with OT-II TCR-transgenic T cells established that the predominant memory set is CD62L(hi), whereas the CD62L(lo) precursors make little… CONTINUE READING