Physiological modulation of voltage-dependent inactivation in the cardiac muscle L-type calcium channel: a modelling study.

@article{Findlay2008PhysiologicalMO,
  title={Physiological modulation of voltage-dependent inactivation in the cardiac muscle L-type calcium channel: a modelling study.},
  author={Ian M. Findlay and Shingo Suzuki and Shingo Murakami and Yoshihisa Kurachi},
  journal={Progress in biophysics and molecular biology},
  year={2008},
  volume={96 1-3},
  pages={
          482-98
        }
}
The inactivation of the L-type Ca2+ current is composed of voltage-dependent and calcium-dependent mechanisms. The relative contribution of these processes is still under dispute and the idea that the voltage-dependent inactivation could be subject to further modulation by other physiological processes had been ignored. This study sought to model physiological modulation of inactivation of the current in cardiac ventricular myocytes, based upon the recent detailed experimental data that… CONTINUE READING
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