Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites.

  title={Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites.},
  author={A Concas and Paolo Follesa and Maria Luisa Barbaccia and Robert H. Purdy and Giovanni Biggio},
  journal={European journal of pharmacology},
  volume={375 1-3},
The possible functional relation between changes in brain and plasma concentrations of neurosteroids and the plasticity of gamma-aminobutyric acid type A (GABA(A)) receptors in the brain during pregnancy and after delivery was investigated in rats. The concentrations in the cerebral cortex and plasma of pregnenolone as well as of progesterone and its neuroactive derivatives allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) and allotetrahydrodeoxycorticosterone (5alpha-hydroxy-3alpha,21… CONTINUE READING


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