Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.

@article{Hallows2003PhysiologicalMO,
  title={Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.},
  author={Kenneth R. Hallows and Gary P Kobinger and J. M. Wilson and Lee Alan Witters and J. Kevin Foskett},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 5},
  pages={
          C1297-308
        }
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated, ATP-gated Cl(-) channel and cellular conductance regulator, but the detailed mechanisms of CFTR regulation and its regulation of other transport proteins remain obscure. We previously identified the metabolic sensor AMP-activated protein kinase (AMPK) as a novel protein interacting with CFTR and found that AMPK phosphorylated CFTR and inhibited CFTR-dependent whole cell conductances when coexpressed with CFTR in… CONTINUE READING

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