Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans.

Abstract

Workers in the reinforced plastics industry are exposed to large quantities of styrene and to small amounts of the carcinogen, styrene-7,8-oxide (SO), in air. Since SO is also the primary metabolite of styrene, we modified a published physiologically based pharmacokinetic (PBPK) model to investigate the relative contributions of inhaled SO and metabolically… (More)

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Cite this paper

@article{TorneroVelez2001PhysiologicalMO, title={Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans.}, author={Rogelio Tornero-Velez and Stuart Rappaport}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2001}, volume={64 2}, pages={151-61} }