Physiological modeling of isoprene dynamics in exhaled breath.
@article{King2010PhysiologicalMO, title={Physiological modeling of isoprene dynamics in exhaled breath.}, author={Julian King and Helin Koc and Karl Unterkofler and Paweł Mochalski and Alexander Kupferthaler and Gerald Teschl and Susanne Teschl and Hartmann Hinterhuber and Anton Amann}, journal={Journal of theoretical biology}, year={2010}, volume={267 4}, pages={ 626-37 } }
158 Citations
Reproducibility and verification of real time breath VOCs concentration data by modeling
- Biology
- 2017
The observed concentration profiles show that the exercise peak for normal isoprene cannot be explained by changes in ventilation and perfusion, and it is suggested that due to an increased peripheral blood flow during exercise, it is washed out and delivered a short peak at the start of exercise.
The role of mathematical modeling in VOC analysis using isoprene as a prototypic example.
- Environmental ScienceJournal of breath research
- 2011
The results presented here may enable a new perspective on the biochemical processes governing isoprene formation in the human body and help to gather the relevant experimental information for understanding the gas exchange phenomena associated with this important VOC.
A modeling-based evaluation of isothermal rebreathing for breath gas analyses of highly soluble volatile organic compounds.
- BiologyJournal of breath research
- 2012
It is demonstrated that the end-tidal breath profiles of such substances during isothermal rebreathing show a characteristic increase that contradicts the conventional pulmonary inert gas elimination theory due to Farhi, and a previously developed mathematical model for the general exhalation kinetics of highly soluble, blood-borne VOCs is used.
Physiological Modeling for Analysis of Exhaled Breath 1
- Biology
- 2013
This paradigmatic example shows that a purely explorative search for VOC biomarkers is not sufficient: in order to make breath tests operational, a thorough quantitative understanding of the underlying gas exchange mechanisms and their sensitivity with respect to physiological factors is needed.
Breath isoprene: muscle dystrophy patients support the concept of a pool of isoprene in the periphery of the human body.
- MedicineBiochemical and biophysical research communications
- 2012
A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
- Environmental ScienceJournal of mathematical biology
- 2011
The chief intention of the present modeling study is to provide mechanistic relationships for further investigating the exhalation kinetics of acetone and other water-soluble species, and is a first step towards new guidelines for breath gas analyses of volatile organic compounds, similar to those for nitric oxide.
VOLATILE ORGANIC COMPOUNDS IN EXHALED BREATH : REAL-TIME MEASUREMENTS , MODELING , AND BIOMONITORING APPLICATIONS
- Biology
- 2012
Reviewing some paradigmatic applications of modeling and simulation in the context of exhaled breath analysis shows how real-time breath profiles of volatile organic compounds can be used to extract in vivo estimates of endogenous quantities that are difficult to access by conventional analytical approaches based on blood, urine, or tissue.
VOLATILE ORGANIC COMPOUNDS IN EXHALED BREATH : REAL-TIME MEASUREMENTS , MODELING , AND BIOMONITORING APPLICATIONS
- Biology
- 2012
Reviewing some paradigmatic applications of modeling and simulation in the context of exhaled breath analysis shows how real-time breath profiles of volatile organic compounds can be used to extract in vivo estimates of endogenous quantities that are difficult to access by conventional analytical approaches based on blood, urine, or tissue.
Measurement of endogenous acetone and isoprene in exhaled breath during sleep.
- Environmental SciencePhysiological measurement
- 2012
Breath acetone andIsoprene profiles exhibited pronounced concentration peaks, which were highly specific for leg movements as scored by tibial electromyography, and baseline isoprene concentrations decreased during the transition from the NREM to the REM phase of a complete sleep cycle.
References
SHOWING 1-10 OF 163 REFERENCES
Isoprene and acetone concentration profiles during exercise on an ergometer.
- Environmental ScienceJournal of breath research
- 2009
Data appear to favor the hypothesis that short-term effects visible in breath isoprene levels are mainly caused by changes in pulmonary gas exchange patterns rather than fluctuations in endogenous synthesis, and hold great potential in capturing continuous dynamics of non-polar, low-soluble VOCs over a wide measurement range.
Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling.
- MedicineJournal of applied physiology
- 2001
It is shown that breath isoprene concentration increases within a few seconds after exercise is started as a result of a rapid increase in heart rate and then reaches a lower steady state when breath rate stabilizes, and reaffirms the possibility that breath hasoprene can be a noninvasive marker of cholesterologenesis if care is taken to measure it under standard conditions at constant heart rate.
Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study.
- Environmental SciencePhysiological measurement
- 2010
These investigations aim at evaluating the impact of breathing patterns, cardiac output or blood pressure on the observed breath concentration and allow for the detection and identification of several VOCs revealing characteristic rest-to-work transitions in response to variations in ventilation or perfusion.
A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
- Environmental ScienceJournal of mathematical biology
- 2011
The chief intention of the present modeling study is to provide mechanistic relationships for further investigating the exhalation kinetics of acetone and other water-soluble species, and is a first step towards new guidelines for breath gas analyses of volatile organic compounds, similar to those for nitric oxide.
Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview
- MedicineWiener klinische Wochenschrift
- 2005
Breath isoprene measurements could potentially be used for mass screening for lipid disorders and could, at minimum, serve as an additional parameter to complement invasive tests for monitoring the efficacy of lipid-lowering therapy, pharmacological and dietary or lifestyle.
A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise.
- BiologyToxicology letters
- 2006
Volatile Alkanes and Increased Concentrations of Isoprene in Exhaled Air during Hemodialysis
- Medicine, BiologyNephron
- 1999
Patients in hemodialysis offer a unique opportunity to investigate in depth the medical, biological and toxicological aspects of isoprene, an unsaturated hydrocarbon the biosynthesis and biological effects of which are the subject of controversy and mounting interest.
Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening.
- Environmental ScienceWiener klinische Wochenschrift
- 2001
Breath isoprene reductions during lipid-lowering therapy were shown to correlate with cholesterol and LDL concentrations in blood and Mass-108, which presumably represents o-toluidine in breath samples, appears to be a currently underestimated carcinoma marker that deserves further investigation.
Diagnostic potential of breath analysis--focus on volatile organic compounds.
- MedicineClinica chimica acta; international journal of clinical chemistry
- 2004
Analysis of volatile disease markers in blood.
- MedicineClinical chemistry
- 2001
The SPME method can detect volatile substances in very low concentrations in the blood of humans and animals and analysis of volatile substancesIn vascular compartments will enlarge the diagnostic potential of breath analysis.