• Medicine, Mathematics
  • Published in
    The Journal of clinical…
    1990
  • DOI:10.1172/JCI114873

Physiological measurements of luminal stirring in the dog and human small bowel.

@article{Levitt1990PhysiologicalMO,
  title={Physiological measurements of luminal stirring in the dog and human small bowel.},
  author={Michael D. Levitt and Julie K. Furne and Alessandra Strocchi and B. W. Anderson and David G. Levitt},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 5},
  pages={
          1540-7
        }
}
The resistance to absorption resulting from poor stirring of luminal contents (RLum) is considered to be equivalent to an unstirred layer of greater than 600 microns in the human small intestine. We measured RLum in the jejunum of conscious dogs by assessing the absorption rate of two rapidly absorbed probes, glucose, and [14C]warfarin. When RLum was expressed as an unstirred layer, the maximal thickness of the unstirred layer (assuming negligible epithelial cell resistance) was only… CONTINUE READING

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  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1995
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In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

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