Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect.

  title={Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect.},
  author={Eckehard Liske and Willy H{\"a}nggi and Hans-Heinrich Henneicke-von Zepelin and N. Boblitz and P W W{\"u}stenberg and Volker Rahlfs},
  journal={Journal of women's health \& gender-based medicine},
  volume={11 2},
OBJECTIVE This study sought to confirm the efficacy and safety of the currently recognized dose of Cimicifugae racemosae rhizoma (40 mg/day) and to evaluate a higher dose and its associated physiological effects. METHODS We conducted a controlled, randomized, double-blinded parallel group study of perimenopausal and postmenopausal women treated with two different doses (39 mg and 127.3 mg) of a unique C. racemosa preparation over a 24-week period. Efficacy and tolerability were determined by… 

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