Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study.

@article{Choi2011PhysiologicalIB,
  title={Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study.},
  author={Jin-Sung Choi and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 6},
  pages={3173-84}
}
We have examined the question of how the level of expression of sodium channel Na(v)1.8 affects the function of dorsal root ganglion (DRG) neurons that also express Na(v)1.7 channels and, conversely, how the level of expression of sodium channel Na(v)1.7 affects the function of DRG neurons that also express Na(v)1.8, using computer simulations. Our results demonstrate several previously undescribed effects of expression of Na(v)1.7: 1) at potentials more negative than -50 mV, increasing Na(v)1… CONTINUE READING
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