Physiological interaction of heart and lung in thoracic irradiation.

  title={Physiological interaction of heart and lung in thoracic irradiation.},
  author={Ghazaleh Ghobadi and Sonja J van der Veen and Beatrijs Bartelds and Rudolf A de Boer and Michael G. Dickinson and Johan R. de Jong and Hette Faber and Maarten Niemantsverdriet and Sytze Brandenburg and Rolf M. F. Berger and Johannes A. Langendijk and Rob P Coppes and Peter van Luijk},
  journal={International journal of radiation oncology, biology, physics},
  volume={84 5},
INTRODUCTION The risk of early radiation-induced lung toxicity (RILT) limits the dose and efficacy of radiation therapy of thoracic tumors. In addition to lung dose, coirradiation of the heart is a known risk factor in the development RILT. The aim of this study was to identify the underlying physiology of the interaction between lung and heart in thoracic irradiation. METHODS AND MATERIALS Rat hearts, lungs, or both were irradiated to 20 Gy using high-precision proton beams. Cardiopulmonary… CONTINUE READING