Physiological implications of the alteration of 6-phosphofructo-1-kinase isozyme pools during brain development and aging.

@article{Dunaway1988PhysiologicalIO,
  title={Physiological implications of the alteration of 6-phosphofructo-1-kinase isozyme pools during brain development and aging.},
  author={George A. Dunaway and Thomas P. Kasten},
  journal={Brain research},
  year={1988},
  volume={456 2},
  pages={310-6}
}
The 6-phosphofructo-1-kinase (PFK) isozyme pools from brains of fetal, neonatal, young adult (3 months) and aged (30 months) rats were studied using chromatographic and immunological techniques. Also, the changing subunit composition of each isozyme pool was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis on 6% slab gels and by immunoblotting with subunit-specific antibodies. The total PFK activity increased over seven-fold during the 30 days following birth, and the L… CONTINUE READING

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