Physiological hypoxia promotes survival of cultured cortical neurons.

@article{Li2005PhysiologicalHP,
  title={Physiological hypoxia promotes survival of cultured cortical neurons.},
  author={Dongdong Li and Jeremy D Marks and Paul T Schumacker and Regina M. Young and James R. Brorson},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 6},
  pages={1319-26}
}
Physiological oxygen (O2) tensions in brain tissues vary widely, from approximately 5 to 40 Torr (1-6%), encompassing levels of moderate hypoxia that have often been considered neurotoxic in vitro. The effects of such hypoxia were examined in embryonic murine cortical neurons cultured continuously from plating in an atmosphere of 1% O2. Remarkably, cortical neurons thrived in 1% O2, with survival at 7-14 days significantly greater than that of neurons cultured in ambient conditions (20% O2… CONTINUE READING
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