Physiological heterogeneity in biofilms

@article{Stewart2008PhysiologicalHI,
  title={Physiological heterogeneity in biofilms},
  author={P. Stewart and M. Franklin},
  journal={Nature Reviews Microbiology},
  year={2008},
  volume={6},
  pages={199-210}
}
Biofilms contain bacterial cells that are in a wide range of physiological states. Within a biofilm population, cells with diverse genotypes and phenotypes that express distinct metabolic pathways, stress responses and other specific biological activities are juxtaposed. The mechanisms that contribute to this genetic and physiological heterogeneity include microscale chemical gradients, adaptation to local environmental conditions, stochastic gene expression and the genotypic variation that… Expand
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