Physiological functions of mitochondrial fusion.

  title={Physiological functions of mitochondrial fusion.},
  author={Hsiuchen Chen and David L. Chan},
  journal={Annals of the New York Academy of Sciences},
In recent years, the dynamic nature of mitochondria has been discovered to be critical for their function. Here we discuss the molecular basis of mitochondrial fusion, its protective role in neurodegeneration, and its importance in cellular function. The mitofusins Mfn1 and Mfn2, GTPases localized to the outer membrane, mediate outer-membrane fusion. OPA1, a GTPase associated with the inner membrane, mediates subsequent inner-membrane fusion. Mutations in Mfn2 or OPA1 cause neurodegenerative… CONTINUE READING
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