Physiological functions of imprinted genes

@article{Tycko2002PhysiologicalFO,
  title={Physiological functions of imprinted genes},
  author={Benjamin Tycko and Ian M. Morison},
  journal={Journal of Cellular Physiology},
  year={2002},
  volume={192}
}
  • B. Tycko, I. Morison
  • Published 1 September 2002
  • Biology, Medicine
  • Journal of Cellular Physiology
Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐origin‐dependent monoallelic expression in the offspring. Embryological and classical genetic experiments in mice that uncovered the existence of genomic imprinting nearly two decades ago produced abnormalities of growth or behavior, without severe developmental malformations. Since then, the identification and manipulation of individual imprinted genes has continued to suggest that the diverse products of these… 
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Recent studies indicate that assisted reproduction technologies (ART) can sometimes affect the epigenetic cycle of imprinting as well, and that this gives rise to imprinting disease syndromes.
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