Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

@article{Munck1984PhysiologicalFO,
  title={Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.},
  author={A. Munck and P. Guyre and N. Holbrook},
  journal={Endocrine reviews},
  year={1984},
  volume={5 1},
  pages={
          25-44
        }
}
  • A. Munck, P. Guyre, N. Holbrook
  • Published 1984
  • Biology, Medicine
  • Endocrine reviews
  • Almost any kind of threat to homeostasis or stress will cause plasma glucocorticoid levels to rise. The increased levels have traditionally been ascribed the physiological function of enhancing the organism's resistance to stress, a role well recognized in glucocorticoid therapy. How the known physiological and pharmacological effects of glucocorticoids might accomplish this function, however, remains a mystery. A generalization that is beginning to emerge is that many of these effects may be… CONTINUE READING
    2,971 Citations

    Paper Mentions

    Interventional Clinical Trial
    Spinal anesthesia blocks acute pain in older patients with femur fracture. Delirium is a common complication seen after femur fracture, affecting approximately 10-16% of patients. It… Expand
    ConditionsCognition Disorders, Cortisol; Hypersecretion, Femoral Fracture
    InterventionDrug
    Glucocorticoid physiology, pharmacology and stress.
    • A. Munck, P. Guyre
    • Biology, Medicine
    • Advances in experimental medicine and biology
    • 1986
    • 157
    MIF as a glucocorticoid-induced modulator of cytokine production
    • 1,074
    Glucocorticoid regulation of inflammation: The plot thickens
    • 47
    Glucocorticoids: Extensive physiological actions modulated through multiple mechanisms of gene regulation
    • 57
    • Highly Influenced
    How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
    • 5,833
    • PDF
    Glucocorticoids, epigenetic control and stress resilience
    • 74
    Thymus as a target tissue of glucocorticoid action: What are the consequences of glucocorticoids thymectomy?
    • 7

    References

    SHOWING 1-10 OF 69 REFERENCES
    Network of immune-neuroendocrine interactions.
    • 376
    Changes in Blood Hormone Levels during the Immune Response
    • 323
    Glucocorticoids inhibit endorphin synthesis by pituitary cells
    • 41