Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

  title={Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.},
  author={A. Munck and P. Guyre and N. Holbrook},
  journal={Endocrine reviews},
  volume={5 1},
  • A. Munck, P. Guyre, N. Holbrook
  • Published 1984
  • Biology, Medicine
  • Endocrine reviews
  • Almost any kind of threat to homeostasis or stress will cause plasma glucocorticoid levels to rise. The increased levels have traditionally been ascribed the physiological function of enhancing the organism's resistance to stress, a role well recognized in glucocorticoid therapy. How the known physiological and pharmacological effects of glucocorticoids might accomplish this function, however, remains a mystery. A generalization that is beginning to emerge is that many of these effects may be… CONTINUE READING
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