Physiological functions and regulation of TRPC channels.

@article{Ong2014PhysiologicalFA,
  title={Physiological functions and regulation of TRPC channels.},
  author={Hwei Ling Ong and Lorena Brito de Souza and Kwong Tai Cheng and Indu S Ambudkar},
  journal={Handbook of experimental pharmacology},
  year={2014},
  volume={223},
  pages={
          1005-34
        }
}
The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1-TRPC7), are Ca(2+)-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues. Of these, TRPC6 has been linked to a channelopathy resulting in human disease. Two key players of the store-dependent regulatory pathway, STIM1 and… CONTINUE READING
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