Physiological functions and pharmacological and toxicological effects of p-octopamine

  title={Physiological functions and pharmacological and toxicological effects of p-octopamine},
  author={Sidney J Stohs},
  journal={Drug and Chemical Toxicology},
  pages={106 - 112}
  • S. Stohs
  • Published 2 January 2015
  • Biology
  • Drug and Chemical Toxicology
Abstract p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases used included PubMed and Google Scholar Advanced. p-Octopamine binds to neuroreceptors in insects that are not present in humans, while exhibiting poor binding to α-1, α-2, β-1, and β-2 adrenergic… 

Fast hepatic biotransformation of p-synephrine and p-octopamine and implications for their oral intake.

The rapid hepatic transformation of p-synephrine and p-octopamine means that their concentration in the portal vein exceeds that in the systemic circulation during absorption, and their metabolic effects will be exerted predominantly in the liver.

Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet

Results suggest that consumption of SOH may be a potential alternative strategy to counteract obesity, and show stronger inhibition of the formation of red-stained lipid droplets than co-treatment with hispidulin and p-synephrine.

p‐Synephrine, ephedrine, p‐octopamine and m‐synephrine: Comparative mechanistic, physiological and pharmacological properties

The effects of ephedrine and m‐synephrine cannot be directly extrapolated to p‐ synephrine and p‐octopamine which exhibit significantly different pharmacokinetic, and physiological/pharmacological properties.

Effect of Aerobic Training and Octopamine Supplementation on the Expression of Octopamine Receptors in the Visceral Adipose Tissue of Rats Exposed to Deep Fried Oils

It seems that AT and Otc alone improve octopamine receptors and lipolysis markers in the visceral adipose tissue of DFO-treated rats, but these two factors have no interactive effects on this pathway.

Molecularly Imprinted Nanoparticles Assay (MINA) in Pseudo ELISA: An Alternative to Detect and Quantify Octopamine in Water and Human Urine Samples

This work is the first attempt to use nanoMIPs in pseudo-ELISA assays to detect octopamine, and shows high affinity to the target molecules and almost no cross-reactivity with analogues ofoctopamine such as pseudophedrine or l-Tyrosine.

Host–guest complexes of cucurbit[6]uril with phenethylamine-type stimulants

Host–guest complexes between the cucurbit[6]uril macrocycle and phenethylamine ‘natural’ stimulants (ephedrine, synephrine and octopamine) have been obtained in the presence of magnesium ions.

A health risk for consumers: the presence of adulterated food supplements in the Netherlands

The aim of this paper is to report the results of analyses of (adulterated) food supplements conducted by the Netherlands Food and Consumer Product Safety Authority between October 2013 and October 2018, finding that daily doses of the substances in the food supplements were sometimes much higher, causing a risk for consumers who are unaware of the presence of these pharmacologically active substances.



Effects of Aging on p‐ and m‐Octopamine, Catecholamines, and Their Metabolizing Enzymes in the Rat

The brain levels of p‐ and m‐octopamine, p‐tyramine, noradrenaline, and dopamine, as well as the activities of metabolizing enzymes, were determined in young adult and aging rats and confirmed that p‐Octopamine and catecholamine metabolisms may have some independent steps and, moreover, that p-octopamines may have a role in the normal activity of the brain.

The physiological disposition of p-octopamine in man

A quantitative difference is seen in the fraction of free p-octopamine which equals the amount of conjugated amine after infusion but is only 1/20 after oral administration which indicates a higher total clearance after an oral dose which consequently explains the diminished efficacy on blood pressure after this route.

A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects

The adrenoreceptor binding characteristics of p-synephrine relative to m- synephrine, norepinephrine, and other amines as related to the observed pharmacological effects are summarized.

m‐Octopamine: Normal Occurrence with p‐Octopamine in Mammalian Sympathetic Nerves

A new specific method for the unequivocal identification and quantitative determination in tissue of the six octopamine and synephrine isomers is developed and it is established that m‐ and p‐octopamine are localized within sympathetic nerve endings.

Characterization of a β-adrenergic-like octopamine receptor from the rice stem borer (Chilo suppressalis)

A rather unique pharmacological profile for CsOA2B2 is observed through measurements of cAMP, the invertebrate counterpart of adrenaline and noradrenaline, which is important for a better functional understanding of this receptor as well as for practical applications in the development of environmentally sustainable pesticides.

Adrenergic Metabolic and Hemodynamic Effects of Octopamine in the Liver

It can be concluded that octopamine accelerates both catabolic and anabolic processes in the liver via adrenergic stimulation, compatible with its reported weight-loss effects in experimental animals.

Octopamine-Mediated Neuromodulation of Insect Senses

The main objective of this review is to discuss significance of octopamine-mediated neuromodulation in insect sensory systems.

Analysis of octopamine in human doping control samples.

Urine samples collected after administration of nutritional supplements containing octopamine and/or synephrine as well as urinary concentration of the target compound increased from baseline levels below the lower limit of detection to 142 µg/mL, while urine samples collected before and after therapeutic application did not yield any evidence for elevated renal excretion ofOctopamine.

Distribution of the Octopamine Receptor AmOA1 in the Honey Bee Brain

The data suggest that one effect of octopamine via AmOA1 in the antennal lobe and mushroom body is to modulate inhibitory neurons.

A putative octopamine/tyramine receptor mediating appetite in a hungry fly

It is suggested that decrease of TA level in the brain likely affects neurons expressing PregOAR/TAR, causing mediation of the sensitivity in the sensillum and/or output of motor neurons for PER.