Physiological functions and pharmacological and toxicological effects of p-octopamine

@article{Stohs2015PhysiologicalFA,
  title={Physiological functions and pharmacological and toxicological effects of p-octopamine},
  author={Sidney J Stohs},
  journal={Drug and Chemical Toxicology},
  year={2015},
  volume={38},
  pages={106 - 112}
}
  • S. Stohs
  • Published 2 January 2015
  • Biology
  • Drug and Chemical Toxicology
Abstract p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases used included PubMed and Google Scholar Advanced. p-Octopamine binds to neuroreceptors in insects that are not present in humans, while exhibiting poor binding to α-1, α-2, β-1, and β-2 adrenergic… 

Fast hepatic biotransformation of p-synephrine and p-octopamine and implications for their oral intake.

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Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet

Results suggest that consumption of SOH may be a potential alternative strategy to counteract obesity, and show stronger inhibition of the formation of red-stained lipid droplets than co-treatment with hispidulin and p-synephrine.

p‐Synephrine, ephedrine, p‐octopamine and m‐synephrine: Comparative mechanistic, physiological and pharmacological properties

The effects of ephedrine and m‐synephrine cannot be directly extrapolated to p‐ synephrine and p‐octopamine which exhibit significantly different pharmacokinetic, and physiological/pharmacological properties.

Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p‐Synephrine

  • S. Stohs
  • Biology
    Phytotherapy research : PTR
  • 2017
This review, as well as several other assessments published in recent years, has concluded that bitter orange extract and p‐synephrine are safe for use in dietary supplements and foods at the commonly used doses.

Effect of Aerobic Training and Octopamine Supplementation on the Expression of Octopamine Receptors in the Visceral Adipose Tissue of Rats Exposed to Deep Fried Oils

It seems that AT and Otc alone improve octopamine receptors and lipolysis markers in the visceral adipose tissue of DFO-treated rats, but these two factors have no interactive effects on this pathway.

Molecularly Imprinted Nanoparticles Assay (MINA) in Pseudo ELISA: An Alternative to Detect and Quantify Octopamine in Water and Human Urine Samples

This work is the first attempt to use nanoMIPs in pseudo-ELISA assays to detect octopamine, and shows high affinity to the target molecules and almost no cross-reactivity with analogues ofoctopamine such as pseudophedrine or l-Tyrosine.

Host–guest complexes of cucurbit[6]uril with phenethylamine-type stimulants

Host–guest complexes between the cucurbit[6]uril macrocycle and phenethylamine ‘natural’ stimulants (ephedrine, synephrine and octopamine) have been obtained in the presence of magnesium ions.

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