Physiological fluid interfaces: Functional microenvironments, drug delivery targets, and first line of defense.

  title={Physiological fluid interfaces: Functional microenvironments, drug delivery targets, and first line of defense.},
  author={Pascal Bertsch and Jotam Bergfreund and Erich J. Windhab and Peter Fischer},
  journal={Acta biomaterialia},
12 Citations

Self-Healing Injectable Hydrogels for Tissue Regeneration.

A critical review of the current state of self-healing injectable hydrogels for tissue regeneration and a practical guide for their rheological analysis are provided to showcase their applicability for regeneration of various tissues and 3D printing of complex tissues and organoids.


Figure 1: a: We performed a long term membrane formation for a single case (0.1% w/w chitosan, 0.1% w/w PFacid , f= 0.5 Hz, γ=0.03%) in order to perform a strain sweep on a thick membrane and define

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Pollution is currently a public health problem associated with different cardiovascular and respiratory diseases. These are commonly originated as a result of the pollutant transport to the alveolar



Complex fluid-fluid interfaces: rheology and structure.

  • G. FullerJ. Vermant
  • Materials Science
    Annual review of chemical and biomolecular engineering
  • 2012
This review presents the methods that have been devised to determine the microstructure of complex fluid-fluid interfaces and reviews of methods for both shear and dilatational measurements are offered here.

Biomimetics of the pulmonary environment in vitro: A microfluidics perspective

Significant hurdles in scaling up current lung-on-chip designs are discussed, from single airway models to more physiologically realistic airway environments that are anticipated to deliver increasingly meaningful whole-organ functions, with an outlook on translational and precision medicine.

Interfacial rheology and direct imaging reveal domain-templated network formation in phospholipid monolayers penetrated by fibrinogen.

This work quantifies the interfacial shear response and directly image the morphological evolution when a model LS monolayer is penetrated by fibrinogen, a protein involved in the blood clotting process and implicated in LS inactivation and the progression of disorders such as acute respiratory distress syndrome.

Active microrheology and simultaneous visualization of sheared phospholipid monolayers

A novel technique that combines active microrheology with fluorescence microscopy to visualize fluid interfaces as they deform under applied stress is presented, allowing structure and rheology to be correlated on the micron-scale in monolayer films.

Interfacial design of protein-stabilized emulsions for optimal delivery of nutrients.

This review focuses on the physico-chemical changes occurring in protein-stabilized oil-in-water emulsions during gastric and small intestine digestion, and on how interfacial engineering could lead to differences in fatty acid release and the potential bioavailability of lipophilic molecules.

Tensiometry and rheology of complex interfaces

Lung surfactant-particles at fluid interfaces for toxicity assessments