Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

@article{PandiPerumal2008PhysiologicalEO,
  title={Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways},
  author={Seithikurippu R Pandi-Perumal and Ilya Trakht and Venkataramanujan Srinivasan and David Warren Spence and Daniel P. Cardinali},
  journal={Progress in Neurobiology},
  year={2008},
  volume={85},
  pages={335-353}
}
Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system. As such it regulates major physiological processes including the sleep wake cycle, pubertal development and seasonal adaptation. In addition to its relevant antioxidant activity, melatonin exerts many of its physiological actions by interacting with membrane MT1 and MT2 receptors and intracellular proteins such as quinone reductase 2, calmodulin, calreticulin and tubulin. Here we… CONTINUE READING

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