Physiological doses of estradiol decrease nocturnal blood pressure in normotensive postmenopausal women.

@article{Cagnacci1999PhysiologicalDO,
  title={Physiological doses of estradiol decrease nocturnal blood pressure in normotensive postmenopausal women.},
  author={Angelo Cagnacci and Lucio Claudio Rovati and Annalisa Zanni and Stefania Malmusi and Fabio Facchinetti and Andrea Volpe},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4 Pt 2},
  pages={H1355-60}
}
The effect of a 2-mo treatment with transdermal estradiol (50 microgram/day) versus placebo on 24 h of blood pressure rhythm was investigated in 18 normotensive healthy postmenopausal women. Whereas daytime blood pressure was not modified, nighttime blood pressure was reduced by estradiol. Estradiol magnified the nocturnal decrement of systolic (14.3 +/- 7.2 vs. 9.8 +/- 6.7 mmHg, P = 0. 0033), diastolic (11.6 +/- 5.0 vs. 7.5 +/- 7.3 mmHg, P = 0.028), and mean (10.8 +/- 5.6 vs. 7.2 +/- 4.5 mmHg… CONTINUE READING

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