Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure.

@article{Iterson2017PhysiologicalDS,
  title={Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure.},
  author={Erik H Van Iterson and Bruce D. Johnson and Barry A. Borlaug and Thomas P. Olson},
  journal={European journal of heart failure},
  year={2017},
  volume={19 12},
  pages={
          1675-1685
        }
}
AIMS Patients with heart failure (HF) with reduced (HFrEF) or preserved (HFpEF) ejection fraction demonstrate an increased ventilatory equivalent for carbon dioxide (V̇E /V̇CO2 ) slope. The physiological correlates of the V̇E /V̇CO2 slope remain unclear in the two HF phenotypes. We hypothesized that changes in the physiological dead space to tidal volume ratio (VD /VT ) and arterial CO2 tension (PaCO2 ) differentially contribute to the V̇E /V̇CO2 slope in HFrEF vs. HFpEF. METHODS AND RESULTS… CONTINUE READING

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