Physiological control of metabolic flux: the requirement for multisite modulation.

  title={Physiological control of metabolic flux: the requirement for multisite modulation.},
  author={David A. Fell and Stuart M. Thomas},
  journal={The Biochemical journal},
  volume={311 ( Pt 1)},
Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes. 

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Enzymes 3rd Ed

E. G. Krebs

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