Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

  title={Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.},
  author={Andrew P. Wojtovich and Charles Owen Smith and Cole M. Haynes and Keith W. Nehrke and Paul S Brookes},
  journal={Biochimica et biophysica acta},
  volume={1827 5},
In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex II in each of these areas, with a focus on how complex II regulates or may be… CONTINUE READING
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