Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans.

@article{Rushakoff1987PhysiologicalCO,
  title={Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans.},
  author={R J Rushakoff and Ira D Goldfine and Jacqueline D. Carter and Rodger A. Liddle},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1987},
  volume={65 3},
  pages={395-401}
}
After a meal, hormones released from the gut potentiate insulin release. This study was undertaken to determine if physiological concentrations of plasma cholecystokinin (CCK) stimulate insulin secretion in man. Employing a specific CCK bioassay, postprandial CCK levels were determined in normal subjects. Ingestion of a mixed liquid meal stimulated an increase in circulating CCK from a mean fasting level of 0.9 +/- 0.2 (SEM) pmol/L to a mean peak level of 7.1 +/- 1.1 pmol/L within 10 min of… CONTINUE READING