Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome.

@article{Cain2001PhysiologicalCO,
  title={Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome.},
  author={Kelvin Cain and Claudia Langlais and X M Sun and David W. Brown and Gerald M. Cohen},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={41985-90}
}
In many forms of apoptosis, cytochrome c released from mitochondria induces the oligomerization of Apaf-1 to form a caspase-activating apoptosome complex. Activation of lysates in vitro with dATP and cytochrome c results in the formation of an active caspase-processing approximately 700-kDa apoptosome complex, which predominates in apoptotic cells, and a relatively inactive approximately 1.4-MDa complex. We now demonstrate that assembly of the active complex is suppressed by normal… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
87 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…