Physiological concentrations of 2-oxoglutarate regulate the activity of phosphoenolpyruvate carboxykinase in liver.

@article{Titheradge1992PhysiologicalCO,
  title={Physiological concentrations of 2-oxoglutarate regulate the activity of phosphoenolpyruvate carboxykinase in liver.},
  author={Michael A. Titheradge and Rich Picking and Robert C. Haynes},
  journal={The Biochemical journal},
  year={1992},
  volume={285 ( Pt 3)},
  pages={
          767-71
        }
}
  • Michael A. Titheradge, Rich Picking, Robert C. Haynes
  • Published 1992
  • Biology, Medicine
  • The Biochemical journal
  • 2-Oxoglutarate was found to inhibit purified rat liver phosphoenolpyruvate carboxykinase when the assay was performed in the direction of either phosphoenolpyruvate or oxaloacetate synthesis. The inhibition was competitive with respect to oxaloacetate or phosphoenolpyruvate, the Ki values being 0.32 +/- 0.04 mM 0.63 +/- 0.19 mM respectively. 2-Oxoglutarate inhibited non-competitively when tested against GTP or Mn2+. The reported cytosolic concentrations of 2-oxoglutarate in rat hepatocytes are… CONTINUE READING

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