Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.

@article{Sakai2004PhysiologicalCO,
  title={Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.},
  author={Hiromi Sakai and Yohei Masada and Hirohisa Horinouchi and Eiji Ikeda and Keitaro Sou and Shinji Takeoka and Makoto Suematsu and Masuhiko Takaori and Koichi Kobayashi and Eishun Tsuchida},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 3},
  pages={
          874-84
        }
}
A hemoglobin vesicle (HbV; diameter 252 +/- 53 nm) or liposome-encapsulated Hb is an artificial oxygen carrier developed for use as a transfusion alternative, and its oxygen-transporting capacity has been well characterized, although critical physiological compartments for the Hb degradation after a massive infusion of HbV and the safety outcome remain unknown. In this study, we aimed to examine the compartments for its degradation by daily repeated infusions (DRI) of HbV, focusing on its… CONTINUE READING
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